Regenerative Medicine Specialist

Gotham Footcare

Podiatrists located in New York, NY

Regenerative Medicine Q&A


Alpha-2-Macroglobulin or A2M

What’s A2M?

Alpha-2-Macroglobulin (A2M) is a natural inhibitor produced by the liver that protects cartilage from proteins known to cause osteoarthritis. This compound is concentrated and then injected directly into affected joints, delivering the A2M supplement to inhibit the progression of arthritis.

How Does A2M Work to Stop Arthritis?

Genetics, lifestyle, and activities can all detrimentally ‘wear and tear’ our joints resulting in pain, swelling, and stiffness. In healthy joints, cartilage works as a buffer to prevent bone-on-bone contact. When a patient suffers from arthritis, chemicals that destroy cartilage called Catabolic Proteases, break down the joint until all cartilage disappears completely, resulting in painful friction of bones rubbing together. A2M halts the progression of osteoarthritis by inactivating and eliminating Catabolic Proteases. Once joint inflammation is subdued, A2M remaining in the joint will promote cartilage tissue growth to restore the joint and reduce pain, swelling, and stiffness.

A2M will relieve pain and halt the progression of osteoarthritis in most patients. The regenerative process will work to rebuild healthy joints, allowing you to return to your active lifestyles with no downtime or adverse harmful effects. One injection could last longer than a year and injections can be repeated without any detrimental side effects commonly associated with corticosteroid injections.

What Conditions does A2M treat?

A2M can eliminate most pain associated with mild to moderate osteoarthritis in the foot and ankle. The injection is used to treat the following foot and ankle conditions: Hallux Limitus/Hallux Rigidus: Painful prominence over the top of the great toe joint accompanied by joint pain and limited mobility resulting in difficulty when running or wearing high heels.

Subtalar Joint Arthritis: Painful prominence at the top of the midfoot that be accompanied by pain when walking barefoot or in unsupported footwear. Ankle Arthritis: Painful popping sensation of the ankle joint with limited mobility during extracurricular activities.

What are the advantages of Regenerative Medicine Injections?

· No risks · No side effects · Effective for a year · Non-invasive


Amniotic Fluid Injections


Amniotic Fluid Injections are also used to aid in the repair of bone fractures, arthritis, and other conditions affecting the foot and ankle. The treatment is performed by injecting the afflicted area. Amniotic Fluid Injections consist of a dense concentration of growth factors and hyaluronic acid that works by lubricating your joints and tendons to ease your pain and restore mobility while increasing the production of proteins, cytokines, and other important compounds to help promote the growth and maintenance of healthy tissue.

The difference in stem cell treatment versus the traditional treatment with cortisone shots is that stem cell therapy treats the root cause of the condition, seeking to change the course of the condition and create healing as whereas Cortisone injections only temporarily lessen your symptoms of pain.

The amniotic stem cell therapy can help patients avoid surgery and obtain pain relief with Achilles tendonitis, ankle arthritis, difficult to heal wounds, plantar fasciitis, and more within two weeks with marked improvement in symptoms.


B12 Injection (Cyanocobalamin)


Vitamin B-12 (cobalamin) is a water-soluble vitamin that plays an essential role in nerve function and regeneration.  In cases of nerve damage such as neuralgia, neuritis, Morton’s neuroma, and peripheral neuropathy, injections of a concentrated B12 dose directly surrounding the affected nerve has been shown to promote nerve regeneration and diminish pathologic nerve pain. 

What Conditions does A B12 Injection Treat?

If you experience a gradual onset of numbness, prickling, tingling, or sharp shooting pains in your feet you may be a candidate for B12 injections.  B12 Injections are used to treat the following foot and ankle condition below:

· Neuralgia
· Neuritis
· Morton’s neuroma
· Peripheral Neuropathy

What are the advantages of Vitamin B12 Injections?

· No risks
· No side effects
· Effective for a year
· Non-invasive 

Protein Rich Plasma (PRP) Injection Therapy


What is PRP therapy used for?

PRP injection therapy is a non-invasive treatment and uses your body’s own healing mechanism. Since it involves your own blood, there are no risks or side effects. Studies have shown that PRP injection is very effective in healing tendonitis and plantar fasciitis and the effects are far superior to a cortisone injection because it delivers a month’s worth of blood nutrient supply in a day to promote fast healing to an area like the Achilles tendon that usually has a limited amount of blood supply at its disposal.

How does PRP work?

PRP Injection involves the following steps:
  1. Drawing blood from your arm and spinning it in a centrifuge to extract PRP
  2. The PRP is then directly injected into the diseased tendon with the help of Ultrasonic imagery.
  3. A CAM (Controlled Ankle Movement) shoe is worn for two weeks to limit movement.

What are the advantages of PRP or Amnio injections to treat Achilles Tendonitis?

· No risks
· No side effects
· Effective for a year
· Non-invasive